Survey on the high prevalence of favism in the Farideh Behbahan Hospital in 1396

Introduction: Glucose 6-phosphate dehydrogenase (G6PD) is the first enzyme in the pathway of pentose phosphate metabolism. This pathway plays an important role in eliminating oxidant metabolites in the body. The deficiency of this enzyme reduces the energy recovery of red blood cells and hemolysis. The aim of this study was to determine the prevalence of favism in Farideh Behbahan Hospital.Materials and Methods: In this descriptive-analytical study, 1928 newborns from the cord were given serum samples and the activity of the G6PD enzyme was determined by fluorescence staining method. Demographic data include the place of residence, gender, history of G6PD deficiency in the family. Data were analyzed using SPSS software and chi-square test. And (p <0.05) is considered significant.Results: Findings indicate that out of 1,928 newborn babies, 143 newborns have g6pd deficiency (13%). 119 (83.2%) males and 24 (16.8%) girls were sampled. The gestational age was less than 30 weeks 4 (2.8%) and 30 to 34 weeks 2 (1.4%) and 34-38 weeks 26 (18.2%) and up to 38 weeks (111%) (77.6%). In this study, the highest frequency of neonatal blood groups is O 58 (40.6%) and A41 (28.7%) B 31 (21.7%) and rh positive. 88 (61.5%) had a history of favism in the mother s family and 55 (38.5%) had no history of favism in the mother s family. The birth weight of 3500 grams is 50 (35%) and 2500 to 3500 grams 77 (53.8) and less than 2500 grams 16 (11.2%). There is also a significant relationship between familial history of favism and vertebrae (p <0.05) and there was a significant relationship between gender and g6pd deficiency (p <0.05).Conclusion: Regarding the prevalence of 13% g6pd deficiency among newborns in the nicu segment, and due to the hemolytic risks that this disease can have for this sensitive group in the future, considering the effectiveness of the family relationship in the first place, the examination and screening of the parents before marriage, and also the examination of the newborns in At birth, it can be effective in reducing the risk of this disease.

Keywords:

Fvism , g6pd deficiency , hyperbilirubinemia , neonatal jaundice