Determination of ETS1 gene single nucleotide polymorphism in Iranian patients with ankylosing spondylitis

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
View: 468

This Paper With 6 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_RHRE-2-4_005

تاریخ نمایه سازی: 7 خرداد 1398

Abstract:

Ankylosing spondylitis (AS) isan inflammatory arthritis with unknown etiology. AS mostly affects the axial skeleton and peripheral joints. The genetic contribution is believed to be a major attributable reason of overall susceptibility to AS. ETS1, also known as the avian erythroblastosis virus E26 (v-ets) oncogene homolog-1 gene, is essential in the development of immune cells in both adaptive and innate immunity. This study investigated the association of single nucleotide polymorphisms (SNPs) in the ETS1 gene (rs1128334 and rs10893872) with ankylosing spondylitis in Iranian population. The study samples comprised 495 AS patients and 490 controls. All samples were selected from the Iranian population. Two SNPs were chosen from the ETS1 gene (rs1128334 and rs10893872), and their association with AS was examined by applying the Real-time PCR allelic discrimination method. The results showed no significant associations between rs1128334 and rs10893872 SNPs and the risk of AS. However, the association between rs10893872 and the Bath Ankylosing Spondylitis Functional Index (BASFI) was significant (p=0.02) after Bonferroni correction, while BASFI was significantly increased in cases with CT in comparison to CC genotype. The results of this study on the Iranian population did not confirm the association of the ETS1 gene SNPs with AS susceptibility; however, the association was significant in Han Chinese populations. The diversity in results among different populations is common in gene association studies of multifactorial diseases. Further investigations will be needed to identify other risk variants of the ETS1 genewhich are correlated with AS susceptibility.

Keywords:

ankylosing spondylitis , ETS1 , Single Nucleotide Polymorphism (SNP)

Authors

Maryam Masoumi

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Mahdi Mahmoudi

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Zahra Malekshahi

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran| Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Jafar Karami

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran| Immunology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Braun J, Sieper J. Ankylosing spondylitis. The Lancet2007; 369(9570):1379-90. doi: ...
  • Gran JT, Husby G: The epidemiology of ankylosing spondylitis. In: ...
  • Fallahi S, Mahmoudi M, Nicknam MH, Gharibdoost F, Farhadi E, ...
  • Sánchez A, Szczypiorska M, Juanola X, Bartolomé N, Gratacós J, ...
  • Brown MA. Progress in the genetics of ankylosing spondylitis. Briefings ...
  • Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, ...
  • Shan S, Dang J, Li J, Yang Z, Zhao H, ...
  • Wang D, John SA, Clements JL, Percy DH, Barton KP, ...
  • Oikawa T, Yamada T. Molecular biology of the Ets family ...
  • Yang W, Shen N, Ye DQ, Liu Q, Zhang Y, ...
  • Sullivan KE, Piliero LM, Dharia T, Goldman D, Petri MA. ...
  • Zhong H, Li XL, Li M, Hao LX, Chen RW, ...
  • Han J-W, Zheng H-F, Cui Y, Sun L-D, Ye D-Q, ...
  • Cui Y, Sheng Y, Zhang X. Genetic susceptibility to SLE: ...
  • Zhang J, Zhang Y, Zhang L, Yang J, Ying D, ...
  • Wang D, John SA, Clements JL, Percy DH, Barton KP, ...
  • Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho IC. ...
  • Linden SVD, Valkenburg HA, Cats A. Evaluation of diagnostic criteria ...
  • van der Heijde D, van der Linden S, Bellamy N, ...
  • Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, ...
  • Jones SD, Porter J, Garrett SL, Kennedy LG, Whitelock H, ...
  • Calin A, Garrett S, Whitelock H, Kennedy L, O hea ...
  • Bidad K, Fallahi S, Mahmoudi M, Jamshidi A, Farhadi E, ...
  • Fallahi S, Jamshidi AR, Bidad K, Qorbani M, Mahmoudi M. ...
  • Roe BA, Crabtree J, Khan A. Methods for DNA isolation. ...
  • Balding DJ. A tutorial on statistical methods for population association ...
  • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a ...
  • Yong Y, Lin H. SHEsis, a powerful software platform for ...
  • Leprince D, Gegonne A, Coll J, De Taisne C, Schneeberger ...
  • Gallant S, Gilkeson G. ETS transcription factors and regulation of ...
  • Barton K, Muthusamy N, Fischer C, Ting C-N, Walunas TL, ...
  • Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki ...
  • Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, ...
  • Chatzikyriakidou A, Voulgari PV, Georgiou I, Drosos AA. Altered sequence ...
  • Zhang Y, Bo L, Zhang H, Zhuang C, Liu R. ...
  • Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, ...
  • Shan S, Dang J, Li J, Yang Z, Zhao H, ...
  • Fridley BL, Biernacka JM. Gene set analysis of SNP data: ...
  • نمایش کامل مراجع