Experimental Solubility of Cefixime Trihydrate in Aqueous Deep Eutectic System

The solubility of drugs and raw materials in solvents and their mixture has an important role in pharmaceutical industry. Among the organic solvents, ionic liquid (IL) has been used as a green solvent. Deep Eutectic Solvents (DES) is a group of ILs that is prepared from reaction a choline chloride and glycolic acid. In this work, the solubility of cefixime trihydrate was measured in water and mixture of water and DES at different weight percent of DES from 313.15 to 323.15 K at atmospheric pressure. The results of experimental solubility data have shown that the solubility of cefixime trihydrate increases with increasing weight percent of DES and temperature.

Keywords:

cefixime trihydrate , Deep Eutectic Solvent , drug solubility