The in-silico analysis of respiratory system for estimating the aerosol deposition during alveoli by using FSI method

During this study the modelling of alveoli system and trajectory of inhaled particles has been determined more accurately by aid of developing the modified three-dimensional model with deformable walls of alveoli. Also, the tissue tension is required to be accounted to calculations for approaching the actual modelling of the lung. Tissue tensions are transferred through the lung parenchyma and produce the pressure gradient. This load expands the alveoli and establishes a sub-ambient (vacuum) pressure within the lungs. Thus, at the alveolar level, the flow field is produced that this flow and alveoli wall continuously affects each other. In this research, we assume that the three dimensional alveolus have a visco-elastic tissue (walls). The relevance between tissue movement and airflow in the alveolus segment is solved by two-way FSI (Fluid Structure Interaction) simulation technique for investigating the effect of pulmonary tissue mechanical properties on particle transport and alveolar flow fields more accurately. Therefore, in order to toward the realistic simulation of pulmonary breathing mechanics the development of a coupled FSI computational model is an important step. We therefore conduct a series of FSI simulations over a range of tissue models and breathing rates. As a result the different fluid flows obtained for the present flexible model against the rigid models and either difference two-way coupling particles trajectory against the one-way particles one.

Keywords:

Alveoli , Two-way FSI (Fluid Structure Interaction) coupling , Particle deposition