Type 2 to type 3 diabetes: causes and interventions

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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CBC15_001

تاریخ نمایه سازی: 29 خرداد 1398

Abstract:

Here, we overview our last achievements in the case of type 2 diabetic (T2D) complicationsincluding glycation-induced protein aggregation arisen from hyperglycemic and oxidativecondition to change protein structure from friend to foe. Most importantly, the conditionmight be brought about a progressive neurodegeneration as type 3diabetes (T3D) emphasizedon sporadic Alzheimer’s disease (SAD) which is likely to be related to unhealthy lifestyle orenvironmental-genetic factors interactions with high prevalence and growing trend. Incontrast to SAD, the familial Alzheimer s disease (FAD) is linked to the autosomal genemutations. Moreover, molecular interference in the range of exacerbation by seeding andmembrane effects and amelioration by interfering small molecules are discussed.

Authors

Mehran Habibi-Rezaei

School of Biology, College of Science, University of Tehran, Tehran, Iran