Novel Binding Models for Interaction of Small Molecules to Proteins
Publish place: 14th Conference on Biophysical Chemistry
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CBC15_004
تاریخ نمایه سازی: 29 خرداد 1398
Abstract:
In characterization, various aspects of macromolecular phenomena in living systems,reversible binding of small molecules to biological macromolecules such as proteins andDNA is of fundamental importance. This is illustrated by the binding curve that measuredexperimentally and analyzed by the binding models in order to characterize its physicalnature and biological importance. This article represents the results of two decades study onexperimental, theoretical, and computational aspects of this phenomenon in our group.Accordingly, the novel analysing models are introduced and the contribution of these workson improvement of our understanding of the functional chemistry of proteins is discussed.The concepts such as binding capacity, mean intrinsic binding quantities and bindingstatistical factors were presented and the experimental analyzing methods were assigned fortheir estimation from raw experimental data.
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Authors
Abdol-Khalegh Bordbar
Department of Chemistry, University of Isfahan, Isfahan, ۸۱۷۴۶-۷۳۴۴۱, Iran