The Effect of Tryptophan Networks in Microtubules on Learning and Memory

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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CBC15_006

تاریخ نمایه سازی: 29 خرداد 1398

Abstract:

There is evidence available that suggests tryptophan administration improves learning and memory. This improvement has been attributed to the role of tryptophan in the CNS, as a precursor for serotonin synthesis. Previous studies have also indicated that hydrophobic compounds which are in structure similar to tryptophan, interact with microtubules, increase the rate of microtubule polymerization, and affect memory. Therefore, the aim of the current study was to investigate the possibility that tryptophan administration could also boost microtubule polymerization and directly result in an improvement of learning and memory. Our results suggest that tryptophan enters the hydrophobic pocket inside the tubulin dimers, which consists of eight tryptophan residues. Not only does this interaction influence the structure of microtubules, but also it positively affects microtubule: assembly. The results of our in vivo studies on rats also suggest that tryp1ophan enhances both working and long-term memory. Thereby, we propose that tryptophan ameliorates resonant energy transfer and electron tunneling in the hydrophobic networks that are present in microtubules, which possibly accounts for the observed improvement in memory.

Authors

Shaghayegh Yousefzadeh

Institute of Biochemistry and Biophysics, University of Tehran, Tehran

Gholamhossein Riazi

Institute of Biochemistry and Biophysics, University of Tehran, Tehran

Ali Mohammad Bananei-Moghaddam

Institute of Biochemistry and Biophysics, University of Tehran, Tehran