A novel eco-friendly procedures, for the Synthesis of Spiro-Oxindole derivatives via alcoholic extractive of Angustifolia leaves as the catalyst andsolvent
Publish place: 20th Iranian Inorganic Chemistry Conference
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
IICC20_093
تاریخ نمایه سازی: 2 تیر 1398
Abstract:
Heterocyclic compounds such as spiro-oxindoles occupy a particular place in chemistry, because of their ‘privileged structure’ in a wide spectrum of pharmacological and organic chemistry. Spirooxindole framework represents the biological and pharmacological activities such as anti-fungal, anti-microbial, anti-oxidant, anti-malarial and anti-tumor. Because of their unique chemopreventive, the expansion of synthetic methods providing easily obtained to this heterocycle are still desirable [1]. Herein, we investigated Angustifolia leaf extract as a new catalyst to a known synthesis of spiro-oxindole derivatives via condensation of isatin derivative, malononitrile, and 1, 3-dicarbonyl compounds under mild reaction conditions (Fig. 1). This efficient route and green methodology for novel synthesis of spiro-oxindoles derivatives has a number of advantages such as short reaction time, high yields (87–95%), use an alcoholic extract of Angustifolia leaves [2] as the solvent and catalyst [3], simple workup procedures and avoidance of hazardous or toxic organic solvents and catalysts. The structure of desired compounds have been described by their physical and spectral data (such as melting points, 1H NMR and 13C NMR spectra and elemental analyses).
Authors
Naser salehi
Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
Malek Taher Maghsoodlou
Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
Zahra aelami
Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran