Leila Soleimany - Department of Biology, Faculty of Science, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Teimour Tabari - DVM. Student, Department of Veterinary Medicine, Shahid Chamran University of Ahvaz, Iran
Mahshad Kalantari - Department of Genetic Science, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
Reza Jahangiri - DVM. Student, Department of Veterinary Medicine, Shahid Chamran University of Ahvaz, Iran

Introduction and Aim: Kinases, which are a group of enzymes belonging to the class 2 enzyme(transferase). By transferring phosphate groups to various proteins, they play a role in regulatingthe broad metabolic pathways. Studies have shown that about 600 genes for kinases are humandoses of the genome, some of which play a role in the onset and spread of many cancers,including breast, and studies have identified the specific inhibitors of this enzyme; Smallmolecules kinase inhibitor has been shown to be effective in the treatment of certain cancers,including breast.Search Methods: This study was conducted through the review article on related topics inGoogle scholar, PubMed, Scopus web sites, and a searchable library of breast tumor, kinase,biological approach, challenge, progress keywords among numerous articles between 1993 and2019, and 67 articles related to the subject was collected and analyzed.Results: In general, inhibitors of kinases that have been confirmed by United States Food andDrug Administration, in some ways, inhibit the enzyme, which include: hydrophobic connectionswith active amino acids, interactions with the amino acid gate kiiper, interaction with aminoacids in the region Enzyme activation; also specific antibodies identified in breast cancer againstkinases including Trastuzum and T-DM1, which inhibit ERBB2 / HER2; and inhibitors of PI3Kand mTOR in breast cancer have been identified in Phase 3 clinical trial. Nowadays, extensivestudies focusing on the identification of small kinase inhibitors of natural nature are ongoing forthe treatment of breast cancer; for example, resveratrol inhibits the expression of ACT kinase inbreast cancer, but the variation in the kinase building expressed in Cancer cells have challengedthe design and manufacture of intruders; for example, Trastuzum did not yield the same results inbreast cancer treatment.Conclusion: The future of breast cancer treatment appears to be highly hopeful and growingbased on the targeting of kinases, and more extensive studies are required.

Breast tumor, kinase, Biological approach, Challenge, Progress