Background: Currently, studying the quality of life of patients and the level of their adaptation totheir disease is considered animportant issue in studies of chronic diseases. Heart failure affects the quality of life of patients invarying degrees.Objectives: The present study aimed to determine the status of quality of life of patients with heartfailure and their level of adaptation to their disease.Methods: In this descriptive-analytical study, 76 patients with heart failure who had referred to oneof the specialized therapy clinics of Shushtar in Khuzestan Province during year 2015 were selectedbased on the convenience sampling method and inclusion criteria. The research tools for collectingthe required data and information included demographic information questionnaire, Minnesotaquality of life questionnaire, and an assessment form designed for patients with heart failure basedon four dimensions of the Roy adaptation model. The data were analyzed using descriptive andanalytical statistics (independent t-test).Results: The results of this study showed that this disease leaves the greatest negative impact on thephysical dimension of quality of life (32.97 _ 6.89). In addition, this disease has put the leastnegative impact on mental dimension of quality of life. Also, the lowest average adaptation wasrelated to the dependence-independence dimension (28.71 _5.54). The results indicated that there isa significant difference between males and females in terms of physical and mental dimensions ofquality if life, with lower averages of both in females (P = 0.037 and P = 0.007, respectively). Thestudy findings also showed that different dimensions of adaptation are the same in males andfemales and there is no significant difference between them (P > 0.05).Conclusions: The present study showed that quality of life and adaptation have a weak status in thestudied patients with heart failure. By taking appropriate measures and training programs, nurses canhelp these patients improve their quality of life and level of adaptation to their disease.