استفاده از متیل فنیدات به منظور خارج سازی از بیهوشی با پروپوفول و کتامین در سگ
Publish place: Iranian Journal of Veterinary Medicine، Vol: 12، Issue: 2
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVM-12-2_005
تاریخ نمایه سازی: 12 تیر 1398
Abstract:
Background: Methylphenidate (MPH) has been used to induce emergence from general anesthesia. OBJECTIVES: The objective of the present study was to evaluate the effect of MPH on recovery from propofol and ketamine anesthesia in dogs. METHODS: Six healthy male mix-breed dogs weighing 21.9 ± 3.9 kg were used in a randomized crossover design. Thirty minutes after premedication with acepromazine (0.1 mg/kg; IM), anesthesia was induced with either IV propofol or ketamine (8 and 15 mg/kg, respectively). Dogs, six minutes after induction, received either IV normal saline or methylphenidate (1 mg/kg) (propofol-saline; propofol-methylphenidate; ketamine-saline; ketamine-methylphenidate). Each dog was anesthetized four times randomly with at least one week interval. RESULTS: No significant differences were observed between propofol-saline and propofol-methylphenidate as well as between ketamine-saline and ketamine-methylphenidate in the times needed for various chronological sequences of recovery (p> 0.05). Recovery in the dogs that received methylphenidate was eventful and associated with some adverse effects. Heart rate showed a decrease in propofol-methylphenidate group compared to the base (p<0.05). Respiratory rate after administration of methylphenidate was more stable than that of saline. CONCLUSIONS: It was concluded that methylphenidate at 1 mg/kg could not shorten recovery time in the dogs premedicated with acepromazine and anesthetized with either propofol or ketamine. Testing lower doses of methylphenidate and using a different premedication agent are recommended for future studies.
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Authors
Hadi Imani Rastabi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Reza Avizeh
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Narges Kavosi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Soroush Sabiza
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
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