پروفایل هورمون های تیروئیدی متعاقب تجویز ایزوفلوپردون و دگزامتازون در گوساله های هلشتاین
Publish place: Iranian Journal of Veterinary Medicine، Vol: 11، Issue: 1
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJVM-11-1_005
تاریخ نمایه سازی: 12 تیر 1398
Abstract:
BACKGROUND: Glucocorticoids are the steroidal drugs which are very widely used in large animal medicine. These agents have advantages in large animals but they have been also associated with many potential adverse effects especially at high doses or prolonged use. OBJECTIVES: The present experimental study was designed to clarify the effects of dexamethasone (DEXA) and isoflupredone (ISO), as the most common glucocorticoids in large animal medicine, on bovine thyroid hormones. METHODS: Ten clinically healthy Holstein calves (6-8 months old) were assigned into 2 equal groups. Dexamethasone (1 mg/kg) and isoflupredone (1 mg/kg) were administered intramuscularly in DEXA and ISO groups, respectively, for two consecutive days. Blood samples were taken at days 0 (before the 1st dose), 1 (before the 2nd dose), 2, 3, 5 and 7, from all studied animals and serum concentrations of T3, T4, fT3 and fT4 were determined in all specimens. RESULTS: Levels of T3 and T4 were decreased significantly after both drugs administrations. The concentrations of T3 and T4 in Iso group were significantly lower than DEXA one (P<0.05). There were no significant changes in serum fT3 and fT4 levels following drugs administrations. CONCLUSIONS: Pharmacological doses of dexamethasone and isoflupredone have suppressive actions on the circulating levels of thyroid hormones in Holstein calves possibly via inhibition of TSH production at hypothalamic-pituitary-thyroid level.
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Authors
Aliasghar Chalmeh
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Mehrdad Pourjafar
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Saeed Nazifi
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Mohammad Reza Zarei
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
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