Comparison of Treatment Response Achieved by Tablet Splitting Versus Whole Tablet Administration of Levothyroxine in Patients with Thyroid Cancer

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JNMB-6-2_004

تاریخ نمایه سازی: 12 تیر 1398

Abstract:

Objective(s): TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical practice. In this study we compared the effect of 150 μg dose of Levothyroxine by use of a100 and a 50 μg tablets or one and half 100 μg tablets in Differentiated thyroid cancer (DTC) patients.Methods: One hundred DTC patients treated with one and half 100 μg Levothyroxine tablets were randomly divided into two groups. The first group continued taking medication as before and the second group received the same daily dose by taking one 100 and one 50 microgram Levothyroxine tablets. The mean changes in TSH and T3 levels and patients weight were compared between the groups.Results: 91 patients completed the study. Levothyroxine consumption pattern, age, gender distribution, weight and TSH levels were comparable between groups at the beginning of the study. The mean change of body weights, serum levels of T3 and TSH showed no significant difference between groups in different time points during the study (P> 0.05).Conclusion: This study showed similar efficacy of tablet splitting and two tablets administration for Levothyroxine; however, patients preferred two tablets at the end of the study. It can be concluded that tablet splitting can be used as an alternative way when the 50 μg tablet is not available.

Authors

Ramin Ashrafpour

School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Narjess Ayati

Nuclear Medicine Research Center, Mashhad University of Medical Science

Ramin Sadeghi

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Samira Zare Namdar

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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