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Why Do the Results of Studies on the Effectiveness of Pralidoxime for Treatment of Organophosphate Poisoning Vary

عنوان مقاله: Why Do the Results of Studies on the Effectiveness of Pralidoxime for Treatment of Organophosphate Poisoning Vary
شناسه ملی مقاله: JR_PJMT-4-3_005
منتشر شده در شماره 3 دوره 4 فصل در سال 1394
مشخصات نویسندگان مقاله:

Ashish Bhalla - Post graduate Institute of Medical Education and Research, Chandigarh, India
Surjit Singh - Post graduate Institute of Medical Education and Research, Chandigarh, India

خلاصه مقاله:
Organophosphate (OP) compounds are frequently used agorchemicals for deliberate self-harm in some parts of the world resulting in high mortality and morbidity. Pralidoxime (2PAM) is the most widely used and trialed oxime for treatment of OP poisoning. There have been variations over the results of trials using 2PAM for OP poisoning. 2PAM therapy has led to favorable outcomes in some studies, whereas it has been associated with unfavorable outcomes or without benefit in the others. Why 2PAM works in some trials and why it does not in the others, has been a key question for medical toxicologists with no definite answer. In this systematic review, we sought to investigate possibilities of the variations in the results of different studies conducted on the effectiveness of 2PAM therapy for OP poisoning and we tried to provide solutions for future studies.

کلمات کلیدی:
Comparative Effectiveness Research, Organophosphate Poisoning, Oximes, Pralidoxime Compounds

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/890673/