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Title

Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease

Year: 1394
COI: JR_PJMT-4-1_003
Language: EnglishView: 192
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Authors

Hamid Reza Rahimi - Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Reza Jaafari - Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
Amir Hooshang Mohammadpour - Department of Clinical Pharmacy and Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
Khalil Abnous - Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract:

Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate Kupffer cells. Curcumin is an active ingredient of the rhizome of turmeric. The substance is shown to have minor adverse effects. As the substance possess low bioavailability in free formulation, different strategies has been conducted to improve its bioavailability which resulted in production of nanomiscels and nanoparticles. Curcumin can provide protection for the liver against toxic effects of alcohol use. Several studies showed curcumin blocks endotoxin-mediated activation of NF-κB and suppresses the expression of cytokines, chemokines, COX-2, and iNOS in Kupffer cells. According to the molecular studies, curcumin inhibits NF-κB signaling pathway, regulates cytokines production and modulates immune response. It has been shown that curcumin can suppress gene expression, especially cytokines genes resulting in down-regulation of tumor necrosis factor-α (TNF-α), interleukin 1 (IL-1), IL-6, IL-8, adhesion molecules (ICAM, VCAM) and C-reactive protein. Hence, curcumin can have therapeutic effects on the majority of chronic inflammatory diseases such as asthma, bronchitis, inflammatory bowel disease, rheumatoid arthritis, ALD, fatty liver, and allergy.

Keywords:

Paper COI Code

This Paper COI Code is JR_PJMT-4-1_003. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/890686/

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Rahimi, Hamid Reza and Jaafari, Mahmoud Reza and Mohammadpour, Amir Hooshang and Abnous, Khalil,1394,Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease,https://civilica.com/doc/890686

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