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Title

Comparison of Alcohol Withdrawal Outcomes in Patients Treated with Benzodiazepines Alone versus Adjunctive Phenobarbital: a Retrospective Cohort Study

Year: 1394
COI: JR_PJMT-4-1_004
Language: EnglishView: 132
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Authors

Lauren Z. Gashlin - Department of Pharmacy, University of Rochester Medical Center, Rochester, USA
Christine M. Groth - Department of Pharmacy, University of Rochester Medical Center, Rochester, USA
Timothy J. Wiegand - Department of Emergency Medicine, University of Rochester Medical Center, Rochester, USA
Elizabeth Ashley - Department of Pharmacy, University of Rochester Medical Center, Rochester, USA

Abstract:

Background: For treatment of severe alcohol withdrawal syndrome, high dose benzodiazepines (BZDs) may cause delirium and over-sedation. Phenobarbital (PBT) is a long-acting barbiturate effective for the treatment of alcohol withdrawal. Given the potential benefits of PBT, we sought to investigate the effectiveness of PBT as adjunctive treatment for alcohol withdrawal. Methods: This was a retrospective cohort study on patients with a diagnosis of alcohol withdrawal who had a CIWA-Ar score > 10 treated with either BZDs alone (BZD alone group) or BZDs with adjunctive PBT (PBT-adjunct group). The patients received at least one dose of PBT in addition to BZDs (variable doses) in the PBT-adjunct group, and three doses of 20 mg diazepam equivalents within 6 hours in the BZD alone group. The primary endpoint was the proportion of patients with a CIWA-Ar score < 10 at 24 hours after initial treatment. Duration of withdrawal and cumulative dose of BZDs were also assessed. Results: Seven subjects in the adjunctive phenobarbital and 21 in the benzodiazepine group were included in the final analysis. Two patients (28.6%) in the PBT-adjunct group and 5 patients (23.8%) in the BZD only group achieved the primary endpoint, though the difference between the two groups was not statistically significant (P = 0.588). The median (IQR) duration of withdrawal symptoms was 44 (12-62) hours in the PBT-adjunct group compared to 53 (37-87) hours in the BZD only group, with no significant difference between the groups (P = 0.249). The median (IQR) cumulative BZD dose requirement (diazepam equivalent) in the PBT-adjunct group was significantly lower than BZD alone group (25 (20-226) vs. 326 (160-550) mg, P = 0.02). Conclusion: PBT appears to be a safe and effective alternative to BZDs for the treatment of alcohol withdrawal in non-critically ill patients and may be BZD sparing.

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Paper COI Code

This Paper COI Code is JR_PJMT-4-1_004. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/890687/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Gashlin, Lauren Z. and Groth, Christine M. and Wiegand, Timothy J. and Ashley, Elizabeth,1394,Comparison of Alcohol Withdrawal Outcomes in Patients Treated with Benzodiazepines Alone versus Adjunctive Phenobarbital: a Retrospective Cohort Study,https://civilica.com/doc/890687

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  • World Health Organization (WHO). Global status report on alcohol and ...
  • Substance Abuse and Mental Health Services Administration. Results from the ...
  • Mayo-Smith MF, Beecher LH, Fischer TL. Management of Alcohol Withdrawal ...
  • Perry EC. Inpatient Management of Acute Alcohol Withdrawal Syndrome. CNS ...
  • Saitz R. Introduction to Alcohol Withdrawal. Alcohol Health Res World ...
  • Sullivan JT, Sykora K, Schneiderman J, Naranjo CA, Sellers EM. ...
  • Spies CD, Otter HE, Huske B, Sinha P, Neumann T, ...
  • Kramp P, Rafaelsen OJ. Delirium Tremens: A double blind comparison ...
  • Hendey GW, Dery RA, Barnes RL, Snowden B, Mentler P. ...
  • Gold JA, Rimal B, Nolan A, Nelson LS. A strategy ...
  • Ives TJ, Mooney AJ, Gwyther RE. Phenobarbital in the treatment ...
  • Young GP, Rores C, Murphy C, Dailey RH. Intravenous Phenobarbital ...
  • Hayner CE, Wuestefeld NL, Bolton PJ. Phenobarbital treatment in a ...
  • Rosenson J, Clements C, Simon B, Vieaux J, Graffman S, ...
  • Dill C, Shin S. High Dose Intravenous Benzodiazepine. Acad Emerg ...
  • University of Pittsburgh. Clinical Quality Improvement of Benzodiazepine-Resistant Alcohol Withdrawal ...
  • Busto U, Sellers EM, Naranjo CA, Cappell H, Sanchez-Craig M, ...
  • Daeppen JB, Gache P, Landry U, Sekera E, Schweizer V, ...
  • Mihic SJ, Harris RA. Hypnotics and Sedatives. In: Brunton LL, ...
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