Association assessment of the Sesn2 gene polymorphisms rs7526084 and rs502273 with the risk of preeclampsia in women of south of Iran
Publish place: 1st international congress of perinatology 7th national congress of perinatology & neonatology
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
PNMED07_030
تاریخ نمایه سازی: 18 تیر 1398
Abstract:
Preeclampsia is one of the most prevalent disorders in pregnancy and considered as a systemic disease. Feto-maternal immune incompatibility, oxidative stress, genetic variants and endothelial cells injuries play an important role in the pathogenesis of the disease. The Sesn2 gene is responsible for coding the Sestrin-2 protein in humans. This gene is a member of the Sestrin gene family. The protein encoded by this gene plays a role in regulating cell growth and survival. The timely expression of the Sesn2 gene significantly reduces the level of ROS and increases the life span of the cell, while suppressing Sesn2 has increased ROS, which decreases the life span of the cell against H2O2. This study aimed to investigate the relationship between rs502273 and rs75260840 polymorphisms of Senes2 gene and the incidence of preeclampsia in women of south of Iran.
Keywords:
In this case-control study , 583 samples including 341 women with preeclampsia and 242 healthy pregnant women as a control group were investigated.
Authors
Sareh Soltani
۱Educational Therapy Center of Hazrat Zeinab(Salamoalah), Shiraz University of medical sciences, Shiraz, Iran
Mahboobeh Nasiri
Departments of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran
Arezoo Dehghani
۳Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran