Sedigheh Amooee - Assistant professor of infertility,OB & GYN department, infertility ward, Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Homeira Vafaei - Associate Professor of maternal fetal medicine, Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Neda Agahi - Resident of gynecology, Maternal-Fetal Medicine Research Center, OB & GYN Ward, Shiraz University of Medical Sciences, Shiraz, Iran
Mehran Karimi - Professor of Oncology, Hematology Research Center,Shiraz University of Medical Sciences, Shiraz, Iran

Background: According to higher rates of IUGR in women with beta-thalassemia minor, and role of CRP level in prediction of pregnant women developed with IUGR. The objective of the present study was to determined relationship between elevated CRP and IUGR in pregnant ladies affected by minor B-thalassemia. Materials and Methods: The study was designed as a prospective case-control one which was conducted on pregnant women referred to Motahari obstetric clinic of Shiraz University of Medical Sciences from March 2015 to February 2016. The pregnant women in case group were β-thalassemia minor and healthy pregnant women was considered as control group. CRP levels and IUGR were investigated and compared between both group at first and third trimesters. Results: Finally, 122 thalassemia and 121 healthy pregnant women were analyzed and compared. In both study group, the most of mothers aged between 19-35 years. In first and third trimesters, women with β-thalassemia minor were favored to IUGR in sonography, were significantly higher than control group. Positive CRP in first trimester was significantly related to IUGR in mothers with minor thalassemia (P<0.001), but this correlation was not significant in third trimester.Conclusion: In conclusion, higher rates of IUGR were found among thalassemic women. On the other hand, there are a positive correlation between elevated CRP and IUGR in thalassemic women at first trimester.

IUGR, CRP, minor thalassemia, pregnancy