Probiotics and Gestational Diabetes: What is its effects

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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PNMED07_113

تاریخ نمایه سازی: 18 تیر 1398

Abstract:

Background:Gestational diabetes mellitus (GDM) is currently defined as carbohydrate intolerance first diagnosed during pregnancy. In the USA, the prevalence of GDM was reported up to 14% of pregnancies and the prevalence of this condition in Iran was reported 4.7%. GDM is associated with increased rates of maternal and fetal morbidity and mortality, both during the pregnancy and in the longer term. Current treatment includes diet with or without medication. Researchers are constantly striving to better understand and develop new therapies for GDM. One such avenue of study involves probiotics, which are live microorganisms that may benefit the health of the host. Throughout pregnancy, the gut microbiota undergoes significant changes; Perturbations in the composition of the gut microbiota have been hypothesized to contribute to the pathogenesis of obesity, inflammation and insulin resistance. It was documented that probiotic administration to pregnant women had favorable effects on metabolic profiles and biomarkers of inflammation and oxidative stress. The aim of this review was to determine the effect probiotic supplementation in pregnant women diagnosed with GDM.Methods: We searched four electronic databases (MEDLINE,EMBASE, CINAHL, Cochrane Database of Systematic Reviews) for the period between January 2008 and February 2019. Results:Laitinen et al. (2009) found that in healthy pregnant women, probiotic supplementation might improve blood glucose control during the third trimester and potentially reduce the risk of developing GDM. Four high quality RCTs (2015-2016) involving 288 participants show that Probiotic supplementation was not effective in decreasing FBG or LDL-cholesterol in women with GDM. However, there was a significant reduction in insulin resistance, which could potentially reduce their requirement for glucose-lowering medication later in their pregnancy. There were no significant differences in gestational weight gain, delivery method or neonatal outcomes between experimental and control groups, and no adverse effects of the probiotics were reported.Conclusion:Although there was a reduction in the incidence of GDM and insulin resistance in most studies, but high quality studies using defined doses of specific bacterial species are required to confirm these findings before probiotics can be recommended to pregnant women to reduce their risk of GDM.

Authors

Mina Taheri

M.S, Faculty of Midwifery Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran

Atefeh Mousavi

B.S of Midwifery, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran

Nehleh Parandavar

M.S, Faculty of Midwifery School of Nursing & Allied Medical Sciences, Jahrom University of Medical Sciences

Zahra Yazdanpanahi

M.S, Faculty of Midwifery Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran