Rahim Vakili - Department of Pediatric Endocrinology and Metabolism, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Medical Genetic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Somayyeh Hashemian - Department of Pediatric Endocrinology and Metabolism, Akbar Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza Jafarzadeh Esfehani - Medical Genetic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Azadeh Zare Feizabadi - Department of Pediatric Endocrinology and Metabolism, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

McCune-Albright Syndrome (MAS) is a rare sporadic disease characterized by bone fibrous dysplasia, Café au lait spots and a variable association of hyperfunction endocrine disorders. There is not any certain treatment available for this syndrome, and both physical and emotional disability in these patients is still a major concern for physicians. In present report we have described a 10- year-old girl, presented with precocious puberty, multiple Café au lait  macules and fibrous dysplasia, successfully treated with pamidronate in a four-year follow-up period.

Children, Iran, Fibrous dysplasia, McCune-Albright syndrome, Precocious puberty