Investigating the anti-apoptotic effect of sesame oil and honey in a novel nanostructure form for treatment of heart failure

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
View: 538

This Paper With 9 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

این Paper در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_NAMJ-4-4_007

تاریخ نمایه سازی: 18 تیر 1398

Abstract:

Objective(s): Sesame oil is a lipophilic compound and has low aqueous solubility and low oral bioavailability. It is possible to enhance sesame oil solubility in aqueous media by applying the microemulsion system in the form of oil-in-water. In this study, the anti-cholesterol and anti-Apoptotic effects of a new combination of sesame oil and honey in a microemulsion form for cardiac muscle cells Apoptosis treatment were investigated. Materials and Methods: Two different formulations were prepared. Tween 80 was used as the main surfactant in both formulations. In the first formulation, glycerin was applied as co-surfactant. Span 80 was applied as a mixed surfactant in the second formulation.Results: Characterization results showed that the average size of droplets of microemulsion samples were in the range of 16.6±0.1-64.6±0.2 nm with a poly dispersity index (PDI) value of less than 0.5. No turbidity and phase sedimentation were observed in certain samples in a period of 6 months after the preparation, which confirmed the high stability of samples. The in-vivo results in Wistar male rats with heart failure showed that applying sesame oil and honey in the microemulsion form caused a significant reduction in the Apoptosis level. In addition, favorable therapeutic effects for microemulsion administration was observed in comparison to the Atorvastatin drug consumption. Furthermore, the protective effect of microemulsion dosage was more obvious with increasing the oil percentage and adding honey as a hydrophilic additive. Conclusion: Results confirmed that the new formulation containing sesame oil and honey as natural components with nano particle size could be useful for cardiac muscle cells Apoptosis treatment.

Authors

Mahmoud Ebrahimi

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Faranak Dehghani

Chemical Engineering Department, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.

Nafiseh Farhadian

Chemical Engineering Department, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.

Mohammad Karimi

Department of Emergency Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Ho K, Pinsky J, Kannel W, Levy D. The epidemiology ...
  • Mosterd A, Cost B, Hoes A, Bruijne Md, Deckers J, ...
  • Cowie M, Wood D, Coats A, Thompson S, Suresh V, ...
  • McMurray J, Petrie M, Murdoch D, Davie A. Clinical epidemiology ...
  • Hunt S, Baker D, Chin M, Cinquegrani M, Feldman A. ...
  • Beltrami C, Finato N, Rocco M, Feruglio G, Puricelli C, ...
  • Narula J, Haider N, Virmani R, DiSalvo T, Kolodgie F, ...
  • Weber K. Extracellular matrix remodeling in heart failure: a role ...
  • Bristow M, Gilbert E, Abraham W, Adams K, Fowler M, ...
  • Sabbah H, Stanley W, Sharov V, Mishima T, Tanimura M, ...
  • Tang W, Francis G. Novel pharmacological treatments for heart failure. ...
  • Shahidi F, Liyana-Pathirana C, Wall D. Antioxidant activity of white ...
  • Chen P, Chien K, Su T, Chang C, Liu TL, ...
  • Jeng K, Hou R, Sesamin and Sesamolin: Nature s Therapeutic ...
  • Shittu L, Bankole M, Ahmed T, Aile K, Akinsanya M. ...
  • Suja K, Jayalekshmy A, Arumughan C. Free radical scavenging behavior ...
  • Kang M, Naito M, Tsujihara N, Osawa T. Sesamolin inhibits ...
  • Sadeghi N, Oveisi M, Hajimahmoodi M, Jannat B, Mazaheri M, ...
  • Frankel S, Robinson G, Berenbaum M. Antioxidant capacity and correlated ...
  • Fahey J, Stephenson K. Pinostrobin from honey and Thai ginger ...
  • Gheldof N, Wang X, Engeseth N. Identification and quantification of ...
  • Beretta G, Granata P, Ferrero M, Orioli M, Facino R.M. ...
  • Inoue K, Murayama S, Seshimo F, Takeba K, Yoshimura Y, ...
  • Blasa M, Candiracci M, Accorsi A, Piacentini M, Albertini M, ...
  • Nagai T, Inoue R, Kanamori N, Suzuki N, Nagashima T. ...
  • Perez E, AJ R.M, Vit P. Antioxidant capacity of Venezuelan ...
  • Küçük M, Kolaylı S, Karaoğlu Ş, Ulusoy E, Baltacı  C, ...
  • Perez R, Iglesias M, Pueyo E, Gonzalez M, Lorenz,o C.d. ...
  • Bogdanov S, Jurendic T, Sieber R, Gallmann P. Honey for ...
  • Khalil M, Sulaiman S, Boukraa L. Antioxidant properties of honey ...
  • Dehghani F, Farhadian N, Golmohammadzadeh S, Biriaee A, Ebrahimi M, ...
  • Narang A, Delmarre S.D, Gao D. Stable drug encapsulation in ...
  • Chaudhary A, Nagaich U, Gulati N, Sharma V.K, Khosa R.L. ...
  • McClements D.J. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft ...
  • Sikarra D, Shukla V, Kharia A.A, Chatterjee D. Techniques for ...
  • Trivedi H, Thakur R, Ray S, Patel K. Design and ...
  • Rhee Y.-S, Choi J.-G., Park E.-S, Chi S.-C. Transdermal delivery ...
  • Zhao X, Zhang Y.L.X. Enhancement of transdermal delivery of theophylline ...
  • Wang S, Ye T, Zhang X, Yang R, Yi X. ...
  • Dizaj S. M. Preparation and study of vitamin A palmitate ...
  • Atashafrooz Z, Dizaj S.M, Sadaghiani A.S. Cucurbita pepo oil as ...
  • Wexler B. Myocardial infarction in young vs old male rats: ...
  • Szab J, Csaky L, Szegi J. Experimental cardiac hypertrophy induced ...
  • Zhang J, Knapton A, Lipshultz S, Weaver J, Herman E. ...
  • Doustar Y, Mohajeri D. The anti-apoptotic effects of atorvastatin in ...
  • نمایش کامل مراجع