Comparison of MnO2 nanoparticles and microparticles distribution in CNS and muscle and effect on acute pain threshold in rats
Publish place: Nanomedicine Journal، Vol: 1، Issue: 3
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
View: 346
This Paper With 11 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_NAMJ-1-3_008
تاریخ نمایه سازی: 18 تیر 1398
Abstract:
Objective(s): Recently, applications of MnO2 nanoparticles and microparticles in industry, pharmacology, and medicine have considerably expanded. Mn distribution and clearance from brain and spinal cord tissue compared with muscle tissue of rats after single subcutaneous injection of nanoparticles and microparticle of MnO2. Pain sensory threshold of rat was evaluated as neurologic consequence of the particles on CNS activity of rats. Materials and Methods: Rats divided to control and two experimental groups. Each experimental group received a single subcutaneous injection of MnO2 nano and micro particles, respectively. Acute pain thresholds of rats were evaluated by tail immersion method and its weight gain was recorded during these weeks. Samples taken from brain, spinal cord and muscle tissues of rats, once every 2 week for 8 weeks. The tissue Mn level was measured by inductively coupled plasma-mass spectrometry method. Results: Both particles size passed from blood barriers. Unlike brain tissue, manganese completely cleared from spinal tissue after 8 weeks in both groups. Clearance of Mn from muscle tissue is not complete in both of the groups. Weight gain of rats in both groups was slower than control rats. In microparticle group, rats showed progressive analgesia (p<0.05). In nanoparticle groups, rats showed hyperalgesia for first 4 weeks and analgesia during remaining weeks.Conclusion: Change in MnO2 particles size affect on Mn distribution and clearance from central nervous system. Effect of particles on whole body metabolism varied with its size too. Finally, comparison of pain response of rats among particle treated groups indicates that neurobiological mechanism affected by particles is varied with their size during times after administration.
Keywords:
Authors
Nahid Nosrati
Department of Biology, Basic Sciences School, Shahed University, Tehran, Iran | Department of Pharmacology, Faculty of Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran
Majid Hassanpour-Ezzati
Department of Biology, Basic Sciences School, Shahed University, Tehran, Iran
Sayyed Zahra Mousavi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran
Mohammad safi Rahmanifar
Department of Biology, Basic Sciences School, Shahed University, Tehran, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :