leila Youseftabar-Miri - Department of Chemistry, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

Egg shell has been utilized as a natural, green, reusable and eco-friendly reagent for the synthesis of spiro[4H-pyran-oxindole] derivatives by one-pot multicomponent reaction of isatins, 1,3-diketones, and malononitrile/ ethyl cyanoacetate. Good functional group tolerance and broad scope of usable substrates are other prominent features of the present methodology.

Spirooxindole, eggshell, heterogeneous catalyst, isatin, green chemistry