Application and comparison of the catalytic activity of Fe3O4 MNPs, Kaolin and Montmorillonite K10 for the synthesis of indole derivatives

Synthesis of indole derivatives was investigated and compared to the reaction of phenylhydrazine and ketones in the presence of the heterogeneous catalysts like kaolinite, montmorillonite K10 and Fe3O4 MNPs in ethanol under reflux conditions. After comparing the HPLC chromatogram of products it was compared and found that kaolin and montmorillonite K10 are better and more efficient candidate than Fe3O4 magnetic nanoparticles for synthesis of indole derivatives. The synthesized compounds have been characterized by 1H-NMR and 13C-NMR. The advantages of this reaction are short reaction time, mild reaction conditions, high catalytic activity in green chemistry, increasing reaction speed without air pollution and good yields.

Keywords:

indole , phenylhydrazine , kaolinite , montmorillonite K10 , Fe3O4 MNPs