Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 13، Issue: 3
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-13-3_004
تاریخ نمایه سازی: 23 تیر 1398
Abstract:
Background and Objective: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries. The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients.Methods: The current study was conducted on 114 cases diagnosed with non-scarring alopecia in Molecular Dermatology Research Center and Pathology Department of Shiraz University of Medical Sciences, Shiraz, Iran. Cases with two 4-mm scalp punch biopsies were selected. Patients’ clinical data were compared with histological findings.Results: Androgenetic alopecia (AGA) was the most common subtype Followed by alopecia areata (AA) and combined AGA/telogen effluvium (TE). Perifollicular inflammation was observed in 21% of AGA with a significant difference in males and females (66.7% vs. 33.3%; P-value <0.05). Clinical and histopathologic diagnoses were correlated in 55% of cases. Maximum correlation was observed in combined AGA and chronic TE (88%). For vertical sections, the diagnostic rate was 33.6%, while 88% for transverse sections.Conclusion: Transverse together with vertical sectioning provides most of the information in non-scarring alopecias, while transverse sectioning is enough to diagnose the majority of non-scarring alopecias. Perifollicular inflammation was observed in a significant number of cases with AGA, more common in males. It is suggested to report such cases as possibly curable.
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Authors
Fatemeh Sari Aslani
Dept. of Pathology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mina Heidari Esfahani
Dept. of Pathology, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran
Mozhdeh Sepaskhah
Dept. of Dermatology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran