Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
View: 393

This Paper With 9 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJP-13-1_006

تاریخ نمایه سازی: 23 تیر 1398

Abstract:

Background & Objective Angiogenesis is an essential component of tumor growth. Expression of PSMA on the neo-vasculature of many solid tumors, including glioblastoma multi-form, has been determined. The pattern of expression suggests that PSMA may play a functional role in angiogenesis. Methods: expression of PSMA in different grades of brain glioma was evaluated by the immunohistochemistry method to determine the probable usefulness of anti-PSMA antibody as complementary target therapy in different grades of glioma. Results: Overall, 72 cases of low (grade I and II) and high (grade III and IV) grade gliomas were evaluated for expression of PSMA. Positive PSMA staining was observed in 12 (33.3%) of high grade and 3 (8.3%) of low grade gliomas. Although, high grade tumors more commonly had positive result for PSMA (P value=0.009), the intensity of staining was significantly stronger in low-grade tumors (P value=0.009). Conclusion: Expression of PSMA in different grades of glioma might provide a basis for further investigations focusing on selective target therapy in combination with the current standard care in all glioma grades, to improve treatment efficacy.

Authors

Hiva Saffar

Dept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Iran

Maryam Noohi

Dept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Iran

Seyed Mohammad Tavangar

Dept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Iran

Hana Saffar

Dept. of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Carlsson SK, Brothers SP, Wahlestedt C. Enmerging treatment strategies for ...
  • Nomura N, Pastorino S, Jiang P, et al. Prostate specific ...
  • Patel MA, Kim JE, Ruzevick J,et al. The Future of ...
  • DeAngelis L. Brain tumors. N  England J Med. 2001;344:114-23. ...
  • Parsa A, Waldron J, Panner A, et al. Loss of ...
  • Wernicke AG, Edgar MA, Lavi E, et al. Prostate Specific ...
  • Shi W, Siemann D. Targeting the tumor vasculature: enhancing antitumor ...
  • Burkhardt J, Hofstetter C, Santillan A, et al. Orthotopic glioblastoma ...
  • Chen K, Huang Y-h, Chen J-l. Understanding and targeting cancer ...
  • pasqualini R, Arap W, McDonald D. Probing the stractural and ...
  • Plate K, Risau W. Angigenesis in malignant gliomas. Glia. 1995;15(3):339-47. ...
  • Scappaticci F. Mechanisms and future directions for angiogenesis based cancer ...
  • Chang S, Reuter V, Heston W, Gaudin P. Metastatic Renal ...
  • Gopalakrishnapillai A, Sonali PB, Jason JC, et al. Assossiation of ...
  • Grau SJ, Trillsch F, Luttichau Iv, et al. Lymphatic phenotype ...
  • Bander N, Milowsky M, Nanus D, et al. Phase I ...
  • Liu H, Moy P, Kim S, al e. Monoclonal antibodies ...
  • Mhawech-Fauceglia P, Zhang S, Terraccino L,et al. prostate-specific membrane antigen ...
  • chang SS, Reuter VE, Heston WDW,et al. Five different Anti-Prostate- ...
  • Akhtar NH, Pail O, Saran A,et al. Prostate-Spaecific Membrane Antigen-Based ...
  • Troyler J, Beckett M, Jr GW. Detection and characterization of ...
  • Tsui P, Rubenstein N, Guinan P. Correlation between PSMA and ...
  • Milowsky M, Nanus D, Kostakoglu L,et al. Vn advanced solid ...
  • Morris M, Pandit-Taskar N, Divgi C,et al. Phase I evaluation ...
  • Haffner M, Kronberger I, Ross J, et al. Prostate-Specific Membrane ...
  • Sacha P, Zamecnik J, Barinka C, et al. Expression of ...
  • Kirsch M, Schackert G, Black P. Anti-angiogenic treatment strategies for ...
  • Roskoski R. Sanitinib: a VEGF and PDGF receptor protein kinase ...
  • Takano S, Kamiyama H, Tsuboi K, Matsumura A. Angiogenesis and ...
  • Grau S, Trillsch F, Herms J, et al. Expression of ...
  • Jenny B, Harrison J, Baetens D, et al. Expression and ...
  • Ferrara N, Hillan K, Novotny W. Bevacizumab(Avastin), a humanized anti-VEGF ...
  • Groot Jd, Fuller G, Kumar A, Piao Y, Eterovic K, ...
  • Brastianos P, Bachelor T. VEGF inhibitors in brain tumors. Clin ...
  • Carbonell W, Ansorge O, Sibson N, Muschel R. The vascular ...
  • Jain R, diTomaso E, Duda D,et al. Angiogenesis in brain ...
  • Leenders W, Kusters B, Verrijp K, et al. Antiangiogenic therapy ...
  • Paez-Ribes M, Allen E, Hudock J, Takeda T, et al. ...
  • Grant C, Caromile L, Ho V,et al. Prostate specific membrane ...
  • نمایش کامل مراجع