Testicular germ cell tumors: a pathologic and demographic study of 106 cases in Hasheminejad hospital

Introduction:Testicular cancer accounts for approximately 1% of all cancers in men.Worldwide testicular cancer has more doubled in the last 40 years,in white men.Testicular cancer is the most common from age 20 years to age 40 years.According to the fact that testicular cancers are common in young men and they are curable. Since Hasheminejad hospital is referral in this field our investigation about seminomal was done there. Methods & materials:This project is a retrospective cross-sectional study.We collected pathological and demographic characteristics of 85 seminomal tumors from 2008-2016,Data was entered in the check list and then we analysed them,the following results were obtained. Results: In our study a total of 106 patients out of 246 with testis cancer were diagnosed with seminoma and non-seminoma tumors. Mean age was 30.25 in seminoma and 28.54 in patients with non-seminoma. The mean size in seminoma was 5.23 cm and in non-seminoma was 4.84 cm. necrosis was detected in 29 cases with seminoma and 59 cases with non-seminoma. The involvement of spermatic cord in seminoma was just present in one case and 2 patients with non-seminoma. Involvement of tunica abuginea was in 22 patients and 35 cases with non-seminoma tumor had this. Tunica vaginalis involvement was detected in one case with seminoma and 5 cases with non-seminoma. Also 7 seminoma had involvement of epididymis and 5 of non-seminoma had this too, Involvement of spermatic cord was present in 4 cases with seminoma and 7 cases with non-seminoma tumors. Vascular invasion was reported in 11 cases with seminoma and 17 cases with non-seminoma. The mean level of BHCG was 90 in seminoma and 416 in non-seminoma, the mean level of AFP in seminoma was 252 and 221 in non-seminoma, and the mean of LDH level in seminoma was 551 and 494 in non-seminoma. At all there was just found an association between level of BHCG and non-seminoma tumors.Conclusion: In comparison of specifications such as age and tumor size and pathologic features there were no significant differences between seminomal and nonseminomal germcell tumors. There was a significant difference in level of BHCG between seminomal and nonseminomal.

Keywords:

testis germ cell tumor , seminomal , non-seminomal