Clinicopathologic features and prognostic factors in multiple myeloma: Survival analysis of 92 cases referred to educational hospitals in Yazd between 2008 to 2014

Background & Objectives: Despite the improved survival of patients in the past decade, multiple myeloma is still a disease without definite cure. In this study, clinicopathological characteristics and prognosis of patients with multiple myeloma were investigated.Materials and Methods: This cross-sectional descriptive study was conducted on the hospital folders of patients with multiple myeloma who presented at educational hospitals in Yazd during 2008 to 2014. All demographic data including age, sex and information on the patient s history, physical examination, laboratory findings including: Beta-2 micro globulin, plasma protein electrophoresis, clinical and pathological features were inserted into a questionnaire which has already been designed. Data were analyzed by statistical software SPSS v17. P-value less than 0.05 was considered statistically significant. Results: Totally, 92 patients were enrolled in study included, 56 (60.9%) men and 36 (39.1%) women with the mean age of 66.46 ± 12.63 years. In 43 (46.7%) of them vertebral involvement was detected. Most of the patients 28 (30.8%) were in the age group between 60-69 years. The mean for survival rate was 41.80± 21.14 months and the mean for plasma cell percentage was 33.20. In multivariate analysis, significant correlation was obtained between presence or absence of bone lytic lesions and mortality (p-value=0.005), and also the percentage of plasma cells and mortality (p-value=0.008), respectivelyConclusion: According to the findings of this study it seems that the survival status of patients with multiple myeloma depends on presence or absence of osteolytic lesions. Other coexist circumstances like as a positive history for bone fractures or the percentage of plasma cells can potentially have an influence on patient s mortality.

Keywords:

multiple myeloma , prognosis , survival rate