The effect of targeting EGFR pathway in glioblastoma multiform

IntroductionGlioblastoma multiforme is an invasive type of brain tumor that penetrates a distinct attack from single glioblastoma cells, which causes brain paranchymal infiltration. Here, we examined the efect of on miR-491 glioma cell lines.MethodsWe chosed miR-491 based on a literature and micro-RNA data base ( target scan & mir walk), cloned that and overexpress in antiglioma cell lines.ResultsWe realized that miR-491 have a tumor supresor effect in glioblastoma. miR-491 overexpression reduced in vitro prolifration and induces appotosis. Quantitative PCR documented that mir-491 can suppres EGFR pathway.ConclusionThis work shows miR-491 as a useful micRNA for glioblastoma suppresion. largely through targeting of EGFR pathway causes reduce prolifration of glioma cell lines

Keywords:

Glioma , Mir-491. EGFR