Amniotic fluid-derived stem (AFS) cell-seeded collagen-glycosaminoglycans scaffoldfor wound healing

In the present study a collagen-glycosaminoglycans scaffold was prepared as an analog of the extracellular matrix (ECM) by a freeze drying method. Appropriate tests related to its use for wound healing (evaluation of the structure by scanning electron microscopy, swelling properties, biodegradability properties, Fourier transform infrared spectroscopy and clinical study) were done on the scaffolds.Amniotic fluid-derived stem (AFS) cell seeded scaffolds were shown to be potentially useful for wound healing. Final investigations after days of treatment confirmed that the wound area was less than the control sample which indicating more rapid healing, wound contraction and covered by epithelial tissue which is expected to accelerate wound healing by scaffold

Keywords:

Wound healing , Extracellular matrix , Collagen-glycosaminoglycan scaffolds , Amniotic fluid-derived stem (AFS) cells , Wound dressings