Ameliorating effects of silymarin loaded PLGA on osteoarthritis in rat

IntroductionPrevious studies demonstrated beneficial effects of Silymarin (SM) on various disease. However, low bioavailability of SM restricted its use.ObjectivesIn present study protective effects of SM loaded Poly Lactic-co-Glycolic Acid nanoparticles (NSM) in Mono iodoacetate (MIA)-induced osteoarthritis was evaluated.MethodsIn experimental groups, fourteen days after injection of MIA (into right knee), SM (50 mg/kg) or NSM (50 mg/kg) were administered daily for two weeks. The joints were removed in 10% formalin for assessment of histological changes. Histological changes of the joints were evaluated by using a modified mankin scoring.ResultsMatrix staining, cellularity and total Mankin scoring of articular cartilage were significantly increased in SM-treated rats in comparison to the MIA group (p < 0.05). These impacts were more pronounced in NSM-treated rats.ConclutionThis information indicate that NSM improves the OA in knee joints ofrats

Keywords:

Articular joint , Silymarin , Mono-iodoacetate , Nano drug , Rat