Neural stem cell transplantation for treatment of amyotrophic lateral sclerosis

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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ITERMED01_163

تاریخ نمایه سازی: 7 مرداد 1398

Abstract:

Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by a progressive degeneration of motor neurons leading to limb paralysis, dysphagia, and respiratory failure. Survival of the patients from symptom onset is 3–5 years. It should be noted that the incidence of ALS is also rising in Iran. The pathophysiological reasons for the ALS are unknown and also there is no an efficient cure for the ALS. Recently, stem-cell therapies have been widely used in degenerative diseases. Among various stem cells, neural stem cells (NSCs) appear to have a higher recovery potential in neurodegenerative diseases because of their special properties. Objectives The present study reviews the some evidence for transplantation of NSCs to the case with ALS. MethodsThe present study reviews some evidence for transplantation of NSCs to the case with ALS.Results Stem cells have emerged as an attractive option in treating ALS because they may modulate the local microenvironment in many ways to rescue diseased motor neurons. This could be through reducing inflammation, releasing growth factors, and the other potential less understood mechanisms. For this goal, researchers have used various types of stem cells, such as peripheral blood, mesenchymal, induced pluripotent stem cells in animal models of ALS. Moreover, in phase, I clinical trial the efficacy of NSCs treatment has been observed in the patients with ALS. ConclusionBased on publications, it has shown that the use of NSCs reduces the symptoms of the disease in and increases survival, as well as greatly improves muscle contraction. In view of all that has been mentioned so far, one may indicate that NSCs can be considered as effective treatments for ALS

Authors

Narges Kalhor

School of medicine, Qom University of Medical science, Iran

Sara Afshari

School of medicine, Qom University of Medical science, Iran

Shima ababzadeh

Department of tissue engineering, Qom University of Medical science, Iran.