Investigation of properties of chemically cross-linked silk nanofibrous mat as a nerve guide
Publish place: 1st International Iranian Tissue Engineering and Regenerative Medicine Congress (ITERM2018)
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ITERMED01_304
تاریخ نمایه سازی: 7 مرداد 1398
Abstract:
The aim of this study was to modify a nanofibrous silk mate with a chemically cross-linker. The nanofibrous mats designed by electrospinning method, then were modified using chemically cross-linker of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) in the presence of N-hydroxysuccinimide (NHS). The samples evaluated by microscopic, mechanical analyses, and cell culture assays with Schwann cells. Results of analyses showed a good resilience and compliance with chemically cross-linker. Cellular experiments showed a suitable cell adhesion and growth for the cross-linked mats without any toxicity. This modified mat appears to have the right organisation for testing in vivo special nerve tissue regeneration
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Authors
Maryam Ebrahimi
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Esmaeil Biazar
Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Jafar Ai
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Saeed Heidari keshel
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran