Self-assembling peptide nanofiber as a bioinspired hydrogel induces bone and nerve repair

Despite the many advances in tissue engineering associated with spinal fractures and spinal cord injuries, both of them yet challenging and controversial in clinics. The high prevalence of spinal fractures and spinal cord injuries, necessitates more attention to restorative and repair fractures and injuries. Meantime, a hydrogel-based scaffolds that fill completely cavities and defect sites and they are favorable integrated throughout the defects are promising and preferable to calcium-phosphate materials such as hydroxyapatite and tricalcium phosphate due to their gelling form and cell encapsulation potential. However, one of the most important properties of a hydrogel-based scaffolds is mimicking of physiological milieu that favorably encapsulate cells and form a 3D extracellular matrix with high pore interconnectivity. It seems that self-assembling peptide nanofiber is a good candidate that covers the most requirements of a spinal ans spinal cord scaffold. It is notable that self-assembling peptide nanofiber that are containing special biological motifs will repair spine fractures and spinal core injuries, as well. Our studies showed that self-f-assembling peptide nanofibers are biocompatible and favorably are integrated into the defects sites. It is worth nothing that implantation of the self-assembling peptide nanofiber in spine not only will repair spine but also, its degradation will stimulate motor neuron recovery and myelination of injured spinal cord under the spine

Keywords:

Self-assembling peptide , Hydrogel , Bone repair , Nerve repair