Corneal regeneration

Cornea is the main refractive component of the eye. Corneal regeneration can be classified into three elements; epithelial, stromal and endothelial regeneration. Epithelial regeneration includes conjunctival-limbal autograft (CLAU), living-related conjunctival-limbal allograft (lr-CLAL), keratolimbal allograft transplantation (KLAL), simple limbal epithelial transplantation (SLET), cultivated limbal epithelial transplantation (CLET), cultivated oral mucosal epithelial transplantation (COMET) and in vivo cultivation of limal epithelial cells. Stromal regeneration is mainly based on using biosynthetic corneal substitutes which offer several significant advantages over native corneas including large-scale production, good manufacturing practices, acellular corneal substitutes circumvent immune rejection induced by allogeneic cells, optical and biomechanical properties of the implants can be adapted to the clinical need. They can be partial versus full thickness, temporary versus permanent, acellular versus cellular, collagen-based, polysaccharide-based, and…. Finally, endothelial regeneration includes endothelial cells culture and transplantation. Interestingly, corneal regeneration is subject to lots of research. Hopefully, new ideas and research will open the way to better vision in the upcoming years

Keywords:

CLAU , lr-CLAL , KLAL , SLET , CLET , COMET