Application of piezoelectric materials in bone tissue engineering

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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ITERMED01_438

تاریخ نمایه سازی: 7 مرداد 1398

Abstract:

In the classical definition, tissue engineering consists of three elements, including cells, scaffolds, and signaling factors. Each of them has its own practical significance. Although biochemical growth factors are often known as signaling factors, but physical, mechanical, and electrical stimuli also play an important role in the tissue regeneration process. That s why many researchers are studying in this area. It is worth noting that such stimulant mechanisms are occurring usually in natural tissues. One of these functions is piezoelectricity, which is also seen in some natural tissues.Piezoelectric materials can generate electrical activity in response to deformation. Materials such as barium titanate, lead zirconate titanate, zinc oxide, quartz, Polyvinylidene fluoride (PVDF) and nylon show piezoelectric property. In 1954, piezoelectricity of bone was reported in its natural and even in acellularized form.According to Wolff s law, healthy bone will adapt to the applied loads; If loading increases, the bone will remodel itself to become stronger and denser and vice versa. It was known that bone-regenerating cells would be triggered by the electric potential gradients that developed in response to applied stress due to its piezoelectric property. Regarding this fact, we are trying to develop a tissue engineering system based on using a barium titanate scaffolds for stimulating cells by applying external ultrasound wave.The initial obtained results indicated that highly porous barium titanate scaffolds coated with Gel/HA nanocomposite has proper mechanical, structural, piezoelectrical and biological properties for being used in bone tissue engineering and further studies on the stimulation of these scaffolds using mechanical stimulatant are under investigation by this group

Authors

Mahmoud Azami

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran