The role of genetic in hearing impairment regenerative medicine

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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ITERMED01_451

تاریخ نمایه سازی: 7 مرداد 1398

Abstract:

Hearing impairment (HI) is the most common sensory disorder in humans, affecting 360 million people worldwide. It affects 1 in 500 newborns and nearly 2/3 of the population older than 70 years old suffer from HI. Damage or loss of the inner ear hair cells and spiral ganglion cells are the main factors of hearing impairment. Unfortunately, damage to mammals auditory sensory cells is irreversible so resulting a permanent disability and until now doesn’t have a treatment.Genetic variation lonely or in collaboration with other factors play prominent role in HI etiology, more than half of congenital hearing loss is due to genetic causes. Moreover, genetic factor plays a critical role in several distinct area from initial damage pathway to active hair cell regeneration therefore genetic manipulation is one of main arm in hearing impairment regenerative medicine. Here, we look to current and future genes application in HI regenerative medicine from three perspectives. Firstly, gene therapy approach, from gene replacement to new genome editing system (CRISPR-cas9) example in HI studies and current clinical trial in hearing impairment treatment. Secondly, genetic implications for cochlear implantation and finally the role of gene expression and gene silencing in auditory cell reprogramming procedure. This presentation will provide an in-depth discussion in next generation genetic methods in regeneration auditory cells

Authors

Masoumeh falah

ENT and Head & Neck Research Center and Department, Iran University of Medical Sciences, Tehran, Iran.