اسماعیل روح پرور باسمنج - ۱دانشگاه تربیت مدرس تهران
شهریار عرب - ۲دانشکده علوم زیستی دانشگاه تربیت مدرس
جواد ظهیری - ۳بیوفیزیک دانشکده علوم زیستی دانشگاه تربیت مدرس تهران ایران

function of RNA molecules often depends on its spatial structure. Hence, designing a RNA strand with a specific structure has always attracted biologists, physicians and pharmacists’ attention. This is known as the inverse folding problem [۱]. We know that the Brute Force method for this issue is a NP-complete problem, so we must use optimization methods to reduce the search space of the problem [۲]. In this study, by breaking down the second structure of RNAs into smaller substructure and using these small substructure as templates, we achieved the best initial sequence of nucleotides [۳]. In this study, we gathered RNAs structural information and created our own database, using various databases such as PDB, nucleic acid database, URSDB, and etc. To obtain the desired sequence, we intended to fracture RNAs into substructures, find the best matching sequence for each segment by homology modeling and merge them into the best initial nucleotide sequence.

: Secondary structure of RNA، inverse folding ، RNA molecular design، homology modeling