Development of gelatin microsphere encapsulated Cu-based metal-organic framework for methotrexate delivery

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

IRCCE05_141

تاریخ نمایه سازی: 17 مرداد 1398

Abstract:

The purpose of the study is to the effective approach for the development of methotrexate (MTX) loaded as an anticancer drug into Cu-based metal-organic framework nanohybrid (Cu-MOF/MTX) inserted in pH-sensitive gelatin microsphere biopolymer (Cu-MOF/MTX@GM). MTX was loaded into two-dimensional tunnels and the empty face-centered cubic lattice of Cu-MOF porous. The developed Cu-MOF/MTX@GM was characterized using SEM, XRD, and FTIR analysis. In vitro drug release was revealed through the comparison of the simulated physiological conditions and tumor tissue environment for showing the MTX release ability of the obtained novel microspheres. According to the obtained results, the developed carrier has promising qualities as an excellent candidate for target delivery of MTX to cancer tissues.

Authors

Parinaz Nezhad-Mokhtari

Polymer Research Laboratory, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz,Tabriz, Iran.

Hessamaddin Sohrabi

Department of analytical chemistry, Faculty of chemistry, University of Tabriz, Tabriz, Iran.