Homa Hajimehdipoor - Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Seyedeh Fatemeh Mirdelami - Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Somayeh Esmaeili - Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Seyed Alireza Mortazavi - Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Background and Objectives: Diarrhea is a disease defined by increase in the frequency of defecation and decrease in the stool consistency which is the cause for mortality of more than two million people annually. Currently, tannins have been used for treatment of diarrhea due to their capability of binding to the proteins of the tissues, producing participates and collapsing the cells in the site of application. A survey in the Iranian traditional medicine manuscripts revealed that oak has been used in pediatric and adult diarrhea while modern studies also admit the efficacy of oak in treatment of the disease. In the present study, the outer part of oak called Jaft has been used in formulating syrup for treatment of diarrhea. Methods: Jaft was provided from Tehran local market, its identity was confirmed and the quality control assessments were carried out. Different formulations of Jaft using various excipients were prepared and their physiochemical characteristics were assessed. The accelerated stability assessments were applied on the products during three months. Results: The final formulation contained 5% Jaft , 60% sugar, 0.18% methyl paraben, 0.02% propyl paraben, 0.2% CMC and 1% honey flavor. The results showed that the syrup possessed pleasant flavor and taste, contained no sediments or sugar crystals in cap locking test. The dried residue, viscosity, pH, density and total tannins content were 63.2%, 229.6 cp, 4.98, 1.245 g/cm3 and 2.3 mg/mL, respectively. No signs of microbial growth were observed. The syrup was stable during the three months period. Conclusion: Regarding the results of the study, the prepared syrup is suitable for industrial scaling up after clinical trials.

Iranian traditional medicine, Oak, quality control, syrup