ICSI outcome in infertile males with round headed sperm who referred to Royan institute

Background: Globozoospermia or round-headed sperm syndrome is a very rare type of teratozoospermia with an incidence of less than 0.1% in infertile men population. The disorder characterized by absent or severely malformed acrosome due to failure in acrosome biogenesis, lead to incapacity of sperm to fertilize the oocyte. ICSI seems to be the main treatment for these patients to overcome infertility.Objective: The aim of this study was to evaluate ICSI outcome of infertile men with round-headed sperm referred to Royan institute.Materials and Methods: This is a retrospective study on ICSI outcome of 163 infertile couples which male partner has more than 50% round head spermatozoa, referring to Royan institute (Tehran, Iran) between years 2008 and 2016.Results: From these 163 patients, 53 couples underwent 66 ICSI cycles. The fertilization rate (FR) was 38%. Afterwards, 43 couples had a total number of 60 embryo transfer. 18 pregnancies out of 66 cycles achieved, showed a 27% pregnancy rate. 16 deliveries out of 66 cycles, 24% delivery rate, with 21 live births (15 male and 6 female) also have been achieved.Conclusion: Regarding the current study results and previous reports, ICSI could be a hopeful plan for treating infertility caused by round-headed spermatozoa, at least until other effective and safe treatments will become available in future.

Keywords:

Globozoospermia , Male infertility , ICSI , Acrosome