Assisted reproductive technology (ART) and birth weights

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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RMED08_190

تاریخ نمایه سازی: 21 مرداد 1398

Abstract:

Background: Recently there has been an increased focus on epigenetic insults in utero predisposing to adult disease. Low birth weight may be a marker for such prenatal insults. At the same time, a growing body of evidence suggests that children conceived through assisted reproductive technologies (ART) are at increased risk for poor perinatal outcomes, including low birth weight.Objective: The goal of our study was to investigate birth weight outcome of singleton children conceived using ART.Materials and Methods: All singleton children conceived using ART at the Maryam infertility center in Beheshti Hospital in Isfahan between January 2017 to June 2018 were studied. Each case child conceived with ART was matched with multiple controls based on plurality, maternal age, year of birth. Data collected included birth weight, maternal characteristics such as age, antepartum complications such as diabetes and preeclampsia, type of delivery (operative or not), and gestational age at delivery. Birth weight was analyzed as a continuous variable in grams. Results: Comparison of duration of pregnancy and birth weight of infants born after infertility treatment confirms a shorter pregnancy span and a lower mean birth weight in infants born after IVF and ICSI. If women with pregnancies after ART deliver before term, neonatal birth weight is significantly lower.Conclusion: There is a specific effect of ART, mainly IVF and ICSI, on both shortening the duration of pregnancy and lowering neonatal birth weight. Both these parameters seem to be interrelated consequences of some modification in the gestational process induced by the infertility treatment. Freezing and thawing of oocytes in the pronucleate stage had a lesser impact on pregnancy span and on neonatal birth weight.

Authors

N Bagheri

Maryam Infertility Center, Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

P Mohammadi

Maryam Infertility Center, Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran- Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran- Gametogenesis Research Center, Kashan University of Medical Scie

Sh Eshaghi

Maryam Infertility Center, Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

N Torkiyan

Maryam Infertility Center, Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran