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Levothyroxine treatment and pregnancy outcome in women with subclinical hypothyroidism: A systematic review and meta-analysis

تعداد صفحات: 1 | تعداد نمایش خلاصه: 94 | نظرات: 0
سال انتشار: 1398
کد COI Paper: RMED08_210
زبان Paper: Englishglish
نسخه کامل Paper در کنفرانس ارائه نشده است و در دسترس نیست.

مشخصات نویسندگان Paper Levothyroxine treatment and pregnancy outcome in women with subclinical hypothyroidism: A systematic review and meta-analysis

S Nazarpour - Department of Midwifery, Varamin-Pishva Branch, Islamic Azad University, Tehran, Iran- Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
F Ramezani Tehrani - Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
M Amiri - Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
R Bidhendi Yarandi - Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

چکیده Paper:

Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction during pregnancy. Despite well-defined clinical guidelines on treatment of overt hypothyroid in pregnant women, there is no consensus on Levothyroxine (LT4) treatment of SCH women.Objective: In this meta-analysis we aimed to evaluate the benefits of Levothyroxine treatment on pregnancy outcomes in SCH women.Materials and Methods: PubMed [including Medline], Web of Science, Wiley, Google Scholar, Science direct and Scopus were searched for retrieving articles published in English language on effects of Levothyroxine treatment on pregnancy outcomes in pregnant women with SCH compared to untreated or healthy controls up to 2018. In this systematic and meta-analysis, both fixed and random effect models were applied to estimate pooled effect size. Heterogeneity and publication bias were evaluated using the I-squared (I2) and Begg’s statistics, respectively.Results: Twelve cohort studies and randomized controlled trials with a total of 11307 participants were analyzed. This meta-analysis showed that pregnant women with SCH treated with levothyroxine had lower chances for pregnancy loss (OR: 0.71, 95% CI: 0.57-0.88; I2=0%) and higher chances for live birth rate (OR: 2.72, 95% CI: 1.44-5.11; I2=25%) than placebo group. Compared to euthyroid women, patients with SCH treated with levothyroxine had a higher odds ratio for preterm labor (OR: 1.80, 95% CI: 1.13-2.86; I2=0%). There was not any significant difference in chances of other adverse maternal complications, obstetrical hemorrhage, and neonatal/NICU admission between patients with SCH treated with levothyroxine and control groups (placebo and euthyroid).Conclusion: This study shows that the effect of treatment with levothyroxine in pregnant women with SCH is not the same for all pregnancy outcomes. Levothyroxine treatment in these patients can reduce the loss of pregnancy. Due to the limited number of studies, further studies are needed to conclude more precisely about other consequences.

کلیدواژه ها:

Subclinical hypothyroidism, Pregnancy, Outcome, Treatment

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https://civilica.com/doc/912303/

کد COI Paper: RMED08_210

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در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,Levothyroxine treatment and pregnancy outcome in women with subclinical hypothyroidism: A systematic review and meta-analysis,هشتمین کنگره بین المللی و جشنواره دانشجویی طب تولید مثل و سومین کنگره بین المللی ژنتیک تولید مثل,Yazd,,,https://civilica.com/doc/912303

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برای بار اول: (1398, Nazarpour, S؛ F Ramezani Tehrani و M Amiri و R Bidhendi Yarandi)
برای بار دوم به بعد: (1398, Nazarpour؛ Ramezani Tehrani و Amiri و Bidhendi Yarandi)
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