The relationship between hyperlipidemia and maternal and neonatal outcomes in pregnant women admitted to Al-Zahra Hospital in Rasht

Background: Concentrations of plasma lipids levels during pregnancy clearly increases. According to some studies, dyslipidemia is effective in the incidence of preeclampsia and insulin resistance.Objective: The present study aimed to examine the relationship between hyperlipidemia and maternal and neonatal outcomes in pregnant women admitted to Al-Zahra Hospital in Rasht.Materials and Methods: In this cross-sectional study, women were divided into two groups of pregnant mothers with hyperlipidemia and normal ones. Data including gestational age at birth, maternal age, maternal BMI, maternal weight gain during pregnancy, gestational diabetes mellitus, preeclampsia, cholestasis, delivery method and neonatal outcomes including birth weight and Apgar score were gathered. Data were analyzed by Chi-square, independent T-test, and Mann- Whitney U test in SPSS 21. To compare the relationship between hyperlipidemia and maternal and neonatal outcomes with controls, the logistic regression test and the Odds ratio were used. P<0.05 indicated statistical significance.Results: Results showed that, the higher the gestational age, the greater the incidence of abnormal lipid parameters. In pregnant women with dyslipidemia in combination with increased TG, CHOL and LDL, and decreased HDL, the incidence rates of gestational diabetes, preeclampsia, cholestasis, FGR, and macrosomia were statistically higher (p<0.05) and controlling dyslipidemia could prevent these disorders.Conclusion: This study suggested that dyslipidemia was associated with some adverse effects of pregnancy and harmful fetal outcomes. Therefore, it seems that adding laboratory assessment of lipid profiles before and during pregnancy can be effective in early diagnosis of dyslipidemia.

Keywords:

Dyslipidemias , Gestational diabetes , Pre-Eclampsia , Fetal macrosomia