Investigation of epigenetic factors involved in male infertility

Background: About 8% of men are treated for infertility problems. Several factors are involved in male infertility, and in general, genetical, epigenetically and non-genetically among the most important factors. The investigation of mitochondrial DNA and diversity of RNAs is one of the genetic causes of male infertility. Several studies have shown that the source of many infertile factors in men is the mitochondrial DNA and RNAs. The most important epigenetic causes associated with males infertility include DNA methylation, genetic marking, and histone changes after translation. In the current study, the diversity of RNAs in sperm, the relationship of males’ infertility with miRNAs, epigenetic changes including DNA methylation, genetic marking, and histone changes after translation have been described.Objective: In the current study, the diversity of RNAs in sperm, the relationship of males’ infertility with miRNAs, epigenetic changes including DNA methylation, genetic marking, and histone changes after translation have been described.Materials and Methods: The present study is an overview based on information collected from published research related to the topic.Results: The role of RNAs in male infertility has been identified, as well as epigenetic signals from the sperm genome are important in the performance of sperms so that any change in this process can change the performance of the sperm.Conclusion: It clear that these factors should be considered as an effective factor in infertility.

Keywords:

Male infertility , Epigenetic factors , RNA