Investigation the association of SLC22A1 gene variants and efficiency of metformin on fetal development

Human placentas express several OCT isoforms (OCT1, OCT2, OCT3, MATE1 and MATE2). Among them Organic cationic transporter 1 (OCT1) that coded by gene SLC22A1 is one of the three similar polyspecific cationic transporters which principally expressed in the liver. Four nonsynonymous SLC22A1 variants that have most widespread been studied are rs12208357, rs34130495, OCT1 420 deletion (rs35167514, rs34305973, rs35191146, rs72552763), and rs34059508.All four variants may have an effect on the pharmacokinetics and pharmacodynamics of metformin. metformin being the first therapeutic option for type 2 diabetes and it is also used to treat polycystic ovary syndrome in women. Either it may indirectly affect fetal development, through altered nutrient delivery or placental growth. In this review we investigate the association of SLC22A1 gene variants and efficiency of metformin on fetal development.

Keywords:

SLC22A1 Polymorphisms , OCT , Fetal development , Metformin