Afsoon Taghavi - Cancer Research Center & Department of Pathology ,Shahid Beheshti University of Medical Sciences.Tehran,IRAN
Gohar Mohammadi - Deputy of Social, ,Shahid Beheshti University of Medical Sciences.Tehran,IRAN

Introduction & Aim: Breast cancer (BC) is the most common cancer associated with deaths in women. As almost metastasis is seen in all cases of the BC deaths. Demographical and pathological features are important issues for treating patients with primary stage BC. So, we studied the demographics and clinical characteristics differences of metastatic and non-metastatic primary BC in a 5 period year. .Methods: In this retrospective study, we have studied 1705 women who were diagnosed for BC from the Bio Bank of the Cancer Research Center of Shahid Beheshti University of Medical Sciences (Tehran, Iran). Inclusion criteria were primary BC (metastatic, non-metastatic and stages I and II) with ER-positive, lymph-node-negative and tumor size <5 cm. Demographic characteristics and clinical data of all individual with breast tissue samples were obtained. Staging of primary BC was determined by physical examination, chest x-ray, and liver ultrasound. The paraffin-embedded pathological block of each sample was stained by H & E stain. Results: In total, we were identified and analyzed 85 samples of BC patient that included 70 non-metastatic, 15 metastatic and 15 healthy age-matched as controls group. There was no significant difference between the metastatic and non-metastatic group in age, marital status, abortion, kind of abortion, smoking, high fat diet, and family history of BC. But a correlation was seen in childbirth and pregnancy rate in metastatic and non-metastatic BC group and a higher percentage of non-metastatic patients had three or less than three times pregnancy or childbirth. Clinical manifestations were showed a significant difference between metastatic and non-metastatic BC groups in the pathological form and invasive to lymphatic vessels. Invasive lobular carcinoma (ILC) and Lymphovascular invasion (LVI) were more common in metastatic and non-metastatic, respectively. Conclusion: The risk of metastasis in primary BC is may associate with Number of pregnancies or childbirth and also we demonstrated that ILC is a significant predictor of metastasis in primary BC patients.