A Green Procedure for One-Pot Synthesis of Quinazolinone Derivatives Using CuFe2O4@SO3H as an Efficient and Reusable Catalystunder Solvent-Free Conditions

Multicomponent reactions (MCRs) are special types of synthetically useful organic reactionsin which three or more different starting materials react to give a final product in a one-potprocedure [1,2].2,3-Dihydroquinazolin-4(1H)-ones are important class of heterocycles with awide range of pharmacological and biological activities [3]. A number of synthetic methods toprepare these compounds have been described in the past few years. Developments of magneticnanoparticles (MNPs) for use as supports and investigations of their catalytic applicationsindicate an important branch of green nanotechnology as they enable environmentallyfriendly and sustainable catalytic processes. By easy recoverable MNPs from reaction media,various protocols by surface modification, binding and self-assembly offer a broad scope ofapproaches for preparing magnetically recyclable catalysts. Copper/iron oxide-based catalystsare environmentally compatible, air and moisture insensitive and separation of the reactionmixture is very easy by using an external magnetic field. Surface modified copper/iron oxideMNPs are a kind of new functional materials which have been widely used in biotechnologyand analysis. In this research, we report a new, simple, mild, and effective procedure for theone-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives via a multi-componentcondensation reaction between aryl aldehydes, isatoic anhydridesand ammonium acetate oramines in the presence of CuFe2O4@SO3H as catalyst with high yields (72-95%) and shorttime. In conclusion we have developed a facile, convenient and environment-friendly multicomponentprotocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones under green condition.