A New Ecofriendly Methodology for the Synthesis of Spiro-Oxindole Derivatives via Alcoholic Extract of Angustifolia Leaves as the Solvent and Catalyst

The spiro-oxindole indwells a special place in heterocyclic chemistry because of the attendanceof this ‘privileged structure’ in a wide spectrum of natural products , medicinal and organicchemistry [1]. Spiro-oxindole scaffold represents the pharmacological properties suchas anti-tumor, anti-fungal, anti-microbial, anti-oxidant, anti-malarial, due to its unique chemopreventiveand biological activities of the spiro-oxindole skeleton, the expansion of syntheticmethods providing facile reaches to this heterocycle are still favorable [2-4]. Herein, we reportAngustifolia leaf extract as a new catalyst to a known synthesis of spiro-oxindole derivativesvia condensation of malononitrile, isatin derivatives, and 1,3-dicarbonyl compounds undermild reaction conditions (Fig. 1). This efficient and green methodology has a number ofadvantages such as short reaction time, high yields (87–95%), use an alcoholic extract of Angustifolialeaves as the solvent and catalyst, simple workup procedures and avoidance of hazardousor toxic catalysts and organic solvents. Chemical structure of all desired structures wasidentified by melting points and spectral data and elemental analyses.