Magnetic Nanoparticles with Acidic Tags Promoted the Synthesis of Pyridine Derivatives viaVinylogous Anomeric Based Oxidation under Mild Conditions

Nowadays, due to the biological importance of pyridine derivatives, these versatile moleculeshave found several applications in both medicinal and industrial fields. Highly substitutedpyridines are applied as nonlinear optical materials, electrical materials, chelating agents andfluorescent liquid crystals. Also, these heterocyclic structures represent varied pharmaceuticalactivities. Pyridine derivatives can be found in several biologically active compounds, likeantitumoral 2-amino-4-aryl-6-dialkylamino-3,5-dicyanopyridines and antiproliferative 2,6-dibenzylamino-3,5-dicyanopyridines [1-3]. In this study, a green protocol has been reportedfor the synthesis of highly substituted pyridine derivatives using magnetic nano particles withacidic tags as recoverable catalyst under solvent free conditions via a vinylogous anomericbased oxidation mechanism. The reported method represents varied merits such as clean reactionprofile, short reaction time, high to excellent yields and simple workup procedure.